Practical Synthesis of α,α-Dibromo Esters from Aldehydes.
J Org Chem
; 89(14): 10384-10387, 2024 Jul 19.
Article
em En
| MEDLINE
| ID: mdl-38980823
ABSTRACT
Herein, we report an efficient and practical method for synthesizing α,α-dibromo esters, which are the precursors of ynolates, through the dibromination of aldehydes followed by oxidative esterification using iodine. Our method was successfully employed in a large-scale synthesis to yield more than 30 g of dibromo esters. These two steps can be performed in a one-pot manner, which makes the method adaptable even for aldehydes having low boiling points.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão