Effect of time since vasectomy on live birth rate of TESEâICSI egg donation cycles and male-related prognostic factors.
Andrology
; 2024 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-38997221
ABSTRACT
BACKGROUND:
Vasectomy is a widely used method of contraception. However, some men may have the desire to become biological fathers again after a period.OBJECTIVE:
To explore the effect of time since vasectomy and different male comorbidities on live birth rates from intracytoplasmic sperm injection cycles using donated oocytes by using testicular spermatozoa obtained by testicular sperm extraction. MATERIALS ANDMETHODS:
This was a retrospective study of 123 couples who underwent a testicular sperm extractionâintracytoplasmic sperm injection cycle after vasectomy using donated oocytes. Subjects were divided into groups according to time since vasectomy and the male risk factor evaluated. The main outcomes measured were live birth rate per embryo transfer, per oocyte donation cycle, and per couple. We assessed the cumulative live birth rate according to the time since vasectomy and considered male comorbidities body mass index, hypertension, diabetes mellitus, dyslipidemia, and smoking.RESULTS:
The overall live birth rate per couple was 59.3% (50.6-68.0). Considering the number of embryo transfer and oocyte donation cycle, the live birth rates were 34.1% (27.8-40.4) and 44.5% (36.9-52.1), respectively. The live birth rate according to time since vasectomy was not statistically different between groups. Consequently, the cumulative live birth rate was similar between the different interval times when considering one to eight embryo transfers (p = 0.74). No statistical differences in live birth rate and cumulative live birth rate were found between groups clustered according to male body mass index, smoking, hypertension, and dyslipidemia. However, diabetic male patients had a significantly lower rate of live birth rate per couple (22.2% [4.94-49.4]) than non-diabetic patients did (62.7% [53.7-71.8]) (p = 0.03), but not in their cumulative live birth rate.CONCLUSIONS:
The time since vasectomy seems to have no detrimental effects on the live birth rate and cumulative live birth rate in testicular sperm extractionâintracytoplasmic sperm injection cycles with donated oocytes. Male diabetes negatively affects the overall live birth rate per couple, but not the cumulative live birth rate. These results could be useful for multidisciplinary patient-tailored counseling, regarding the chance of having a pregnancy and facilitating the decision-making process of the fertility specialists.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Andrology
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Espanha