Telomere Elongation During Pre-Implantation Embryo Development.
Adv Anat Embryol Cell Biol
; 238: 121-129, 2024.
Article
em En
| MEDLINE
| ID: mdl-39030357
ABSTRACT
The primary mechanism of telomere elongation in mammals is reverse transcription by telomerase. An alternative (ALT) pathway elongates telomeres by homologous recombination in some cancer cells and during pre-implantation embryo development, when telomere length increases rapidly within a few cell cycles. The maternal and paternal telomeres in the zygote are genetically and epigenetically distinct, with differences in telomere length and in chromatin packaging. We discuss models for how these asymmetries may contribute to telomere regulation during the earliest embryonic cell cycles and suggest directions for future research.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Telômero
/
Desenvolvimento Embrionário
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Adv Anat Embryol Cell Biol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos