The clinical relevance of MOG antibody testing in cerebrospinal fluid.

Reynolds, Molly; Tan, Irene; Nguyen, Kristy; Merheb, Vera; Lee, Fiona X Z; Trewin, Benjamin P; Lerch, Magdalena; Shah, Snehal; Wolfe, Nigel; Buzzard, Katherine; Lechner-Scott, Jeannette; Fabis-Pedrini, Marzena; Fok, Anthony; John, Nevin; Kneebone, Chris; Yiannikas, Con; Brown, David A; Kermode, Allan G; Reddel, Stephen; Dale, Russell C; Brilot, Fabienne; Ramanathan, Sudarshini

Reynolds, Molly; Tan, Irene; Nguyen, Kristy; Merheb, Vera; Lee, Fiona X Z; Trewin, Benjamin P; Lerch, Magdalena; Shah, Snehal; Wolfe, Nigel; Buzzard, Katherine; Lechner-Scott, Jeannette; Fabis-Pedrini, Marzena; Fok, Anthony; John, Nevin; Kneebone, Chris; Yiannikas, Con; Brown, David A; Kermode, Allan G; Reddel, Stephen; Dale, Russell C; Brilot, Fabienne; Ramanathan, Sudarshini.

Afiliação

Reynolds M; Translational Neuroimmunology Group, Kids Neuroscience Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Tan I; Department of Neurology, Concord Hospital, Sydney, Australia.
Nguyen K; Department of Radiology, Concord Hospital, Sydney, Australia.
Merheb V; Brain Autoimmunity Group, Kids Neuroscience Centre, Children's Hospital at Westmead, Sydney, Australia.
Lee FXZ; Brain Autoimmunity Group, Kids Neuroscience Centre, Children's Hospital at Westmead, Sydney, Australia.
Trewin BP; Brain Autoimmunity Group, Kids Neuroscience Centre, Children's Hospital at Westmead, Sydney, Australia.
Lerch M; Translational Neuroimmunology Group, Kids Neuroscience Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Shah S; Sydney Medical School and Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Wolfe N; Translational Neuroimmunology Group, Kids Neuroscience Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Buzzard K; Department of Neurology, Perth Children's Hospital, University of Western Australia, Perth, Australia.
Lechner-Scott J; Department of Neurology, Blacktown Hospital, Sydney, Australia.
Fabis-Pedrini M; MS and Neuroimmunology Service, Royal Melbourne Hospital, Melbourne, Australia.
Fok A; Hunter Medical Research Institute, Faculty of Medicine and Public Health, University of Newcastle, Newcastle, Australia.
John N; Department of Neurology, John Hunter Hospital, Newcastle, Australia.
Kneebone C; The Perron Institute for Neurological and Translational Science, University of Western Australia, Perth, Australia.
Yiannikas C; The Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Australia.
Brown DA; Department of Neuroscience, Monash Health, Melbourne, Australia.
Kermode AG; Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia.
Reddel S; Department of Neuroscience, Monash Health, Melbourne, Australia.
Dale RC; Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia.
Brilot F; Department of Neurology, Royal Adelaide Hospital, Adelaide, Australia.
Ramanathan S; Inner West Neurology, Burwood, Sydney, Australia.

Ann Clin Transl Neurol ; 2024 Jul 28.

Article em En | MEDLINE | ID: mdl-39073255

ABSTRACT

ABSTRACT

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is diagnosed by serum MOG-immunoglobulin G (MOG-IgG) in association with typical demyelination. 111/1127 patients with paired CSF/serum samples were seropositive for MOG-IgG. Only 7/1016 (0.7%) seronegative patients had CSF-restricted MOG-IgG. While 3/7 patients had longitudinally extensive transverse myelitis, four had a confirmed alternate diagnosis (three multiple sclerosis, one CNS vasculitis). In a national referral setting, CSF-restricted MOG-IgG had a low sensitivity (2.63%, 95%CI 0.55-7.50%) and low positive predictive value (1.97%, 95%CI 0.45-8.13%). We strongly recommend serum as the preferred diagnostic biospecimen, and urge caution in the interpretation of CSF-restricted MOG-IgG in patients without clinico-radiological features consistent with MOGAD.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Ann Clin Transl Neurol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália

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