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Impact of type 2 diabetes and its duration on incidence rates of dementia death and medication prescription in the Australian population during 2003-2016.
Mehta, Kanika; Magliano, Dianna J; Carstensen, Bendix; Salim, Agus; Morton, Jedidiah I; Abimanyi-Ochom, Julie; Anstey, Kaarin J; Shaw, Jonathan E; Sacre, Julian W.
Afiliação
  • Mehta K; Baker Heart and Diabetes Institute, Melbourne, Australia; Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Geelong, Australia. Electronic address: kanika.mehta@baker.edu.au.
  • Magliano DJ; Baker Heart and Diabetes Institute, Melbourne, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
  • Carstensen B; Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Salim A; Baker Heart and Diabetes Institute, Melbourne, Australia; Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia; School of Mathematics and Statistics, The University of Melbourne, Melbourne, Australia.
  • Morton JI; Baker Heart and Diabetes Institute, Melbourne, Australia; Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia.
  • Abimanyi-Ochom J; Deakin Health Economics, School of Health and Social Development, Institute for Health Transformation, Faculty of Health, Deakin University, Geelong, Australia.
  • Anstey KJ; School of Psychology, University of New South Wales, Sydney, Australia; Neuroscience Research Australia, Sydney, Australia; UNSW Ageing Futures Institute, University of New South Wales, Sydney, Australia.
  • Shaw JE; Baker Heart and Diabetes Institute, Melbourne, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
  • Sacre JW; Baker Heart and Diabetes Institute, Melbourne, Australia.
Diabetes Res Clin Pract ; 216: 111795, 2024 Oct.
Article em En | MEDLINE | ID: mdl-39084293
ABSTRACT

AIMS:

To quantify rates of dementia treatment and death among Australians with type 2 diabetes relative to those without diabetes using linked national registries of Australia.

METHODS:

The study included 891,418 people with type 2 diabetes registered on the National Diabetes Services Scheme and a randomly sampled, population-based comparison group (n = 1,131,369). Outcomes included dementia death (all-cause dementia, Alzheimer's disease (AD) or vascular dementia), and first prescription of cholinesterase inhibitors or memantine.

RESULTS:

Excess dementia risk was observed in the diabetes group for the composite outcome of all-cause dementia death or dementia medication prescription but varied with age at diabetes diagnosis and its duration. At age 70, the rate of dementia death/medication prescription was ∼1.3 (95% CI 1.2, 1.3) and 1.1 (95% CI 1.1, 1.2) times higher in people with ten and five years of diabetes duration, respectively. Individual outcomes showed that diabetes was associated with a higher incidence of vascular dementia death, whereas an increased risk of AD death was only observed beyond âˆ¼10 years of diabetes duration. Further, the incidence of dementia medication prescription was lower among people with diabetes.

CONCLUSIONS:

A higher incidence of AD death in the setting of 10+ years of diabetes duration coupled with a lower incidence of AD treatment suggests an under-recognition of this dementia phenotype among people with type 2 diabetes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Demência / Diabetes Mellitus Tipo 2 Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Oceania Idioma: En Revista: Diabetes Res Clin Pract Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Demência / Diabetes Mellitus Tipo 2 Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Oceania Idioma: En Revista: Diabetes Res Clin Pract Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2024 Tipo de documento: Article