A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice.
Nat Neurosci
; 27(9): 1758-1773, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39095587
ABSTRACT
Hypothalamic gonadotropin-releasing hormone (GnRH) neurons regulate fertility and integrate hormonal status with environmental cues to ensure reproductive success. Here we show that GnRH neurons in the olfactory bulb (GnRHOB) of adult mice can mediate social recognition. Specifically, we show that GnRHOB neurons extend neurites into the vomeronasal organ and olfactory epithelium and project to the median eminence. GnRHOB neurons in males express vomeronasal and olfactory receptors, are activated by female odors and mediate gonadotropin release in response to female urine. Male preference for female odors required the presence and activation of GnRHOB neurons, was impaired after genetic inhibition or ablation of these cells and relied on GnRH signaling in the posterodorsal medial amygdala. GnRH receptor expression in amygdala kisspeptin neurons appear to be required for GnRHOB neurons' actions on male mounting behavior. Taken together, these results establish GnRHOB neurons as regulating fertility, sex recognition and mating in male mice.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bulbo Olfatório
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Comportamento Sexual Animal
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Hormônio Liberador de Gonadotropina
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Órgão Vomeronasal
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Neurônios
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Odorantes
Limite:
Animals
Idioma:
En
Revista:
Nat Neurosci
/
Nat. neurosci
/
Nature neuroscience
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
França