Prenatal exposure to metals and autism spectrum disorder: Current status and future directions.
Curr Opin Toxicol
; 26: 39-48, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-39119269
ABSTRACT
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with genetic and environmental contributors to etiology. Many metals have the potential to be neurotoxic and their exposures are widespread. The field of metals exposure and ASD research is emerging, and in this review article we assess the current state of the literature, with emphasis on the previous two years. Epidemiology studies are discussed with respect to exposure timing, exposure matrix, and outcome assessment. Toxicology studies are described for exposure dosing and timing, as well as behavioral and molecular outcomes. Further epidemiological and toxicological investigations can identify the timing and importance of metals as ASD risk factors and uncover biological mechanisms for risk mitigation and therapeutic strategies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Curr Opin Toxicol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos