Your browser doesn't support javascript.
loading
Cathepsin V is a useful prognostic factor for colorectal cancer.
Lee, Moon-Soo; Kim, Chang-Nam; Kang, Dong Wook; Kim, Joo Heon.
Afiliação
  • Lee MS; Department of Surgery, Eulji Medical Center, Daejeon, Republic of Korea.
  • Kim CN; Department of Surgery, Eulji Medical Center, Daejeon, Republic of Korea.
  • Kang DW; Department of Pathology, Eulji Medical Center, Daejeon, Republic of Korea.
  • Kim JH; Department of Pathology, Eulji Medical Center, Daejeon, Republic of Korea. Electronic address: kjh2000@eulji.ac.kr.
Pathol Res Pract ; 262: 155531, 2024 Oct.
Article em En | MEDLINE | ID: mdl-39153237
ABSTRACT
Molecular studies have identified various treatment-related prognostic molecules to enhance the effectiveness of colorectal cancer (CRC) treatment and improve survival rates. The expression of cathepsin V in gastrointestinal cancer cells prompted an investigation into its potential as a prognostic indicator for CRC. The evaluation of cathepsin V expression and its clinicopathological significance was conducted through immunohistochemistry in a tissue microarray, encompassing 142 CRC and normal colorectal tissues. Overall and disease-free survival rates, based on cathepsin V expression levels, were assessed using the Kaplan-Meier method and compared utilizing the log-rank test. Univariate and multivariate analyses, employing a Cox proportional hazards model, were performed to identify prognostic factors. Cathepsin V expression exhibited no correlation with age, sex, tumor location, tumor size, or histological grade. However, it was significantly correlated with depth of tumor invasion, regional lymph node (LN) metastasis, distant metastasis, and lymphovascular involvement (all p<0.001). Overall and disease-free survival rates were significantly better with low cathepsin V expression than with high expression (p<0.001). Univariate analysis identified several prognostic factors, including histological grade (low vs. high), tumor size (≤ vs. >5 cm), tumor depth (T1 vs. ≥T2), regional LN metastasis, distant metastasis, tumor-node-metastasis (TNM) stage (Stage I vs ≥II), lymphovascular involvement, and cathepsin V expression. Multivariate analysis revealed that tumor depth, distant metastasis, and cathepsin V expression are independent predictors of poor survival. Cathepsin V is frequently expressed in CRC, and its high expression is associated with poor prognosis. Therefore, cathepsin V is a useful prognostic marker for CRC.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Biomarcadores Tumorais / Catepsinas Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Pathol Res Pract Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Biomarcadores Tumorais / Catepsinas Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Pathol Res Pract Ano de publicação: 2024 Tipo de documento: Article