Iron-Catalyzed Chemoselective Transfer Hydrogenation of α,ß-Unsaturated Ketones Using H2O as a Surrogate of Hydrogen.
J Org Chem
; 2024 Aug 18.
Article
em En
| MEDLINE
| ID: mdl-39155442
ABSTRACT
Sustainable and highly economical iron-catalyzed chemoselective reduction of CâC of α,ß-unsaturated ketones has been established under mild reaction protocols. Water is used as a green and abundant surrogate of hydrogen and is scarcely used in organic synthetic transformations as a source of hydrogen. The developed protocol offers a broad spectrum for chemoselective transfer hydrogenation of α,ß-unsaturated ketones. Moreover, the method was found to be highly effective for aryl and ferrocenyl α,ß-unsaturated ketones consisting of one or two double bonds and with multiple functionalities. Moreover, the present method avoids prolonged reaction time, provides a wide range of substrates with excellent yield, and circumvents the tedious chromatographic workup.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia