Parallel signatures of cognitive maturation in primate antisaccade performance and prefrontal activity.

ABSTRACT

The ability to suppress inappropriate actions and respond rapidly to appropriate ones matures late in life, after puberty. We investigated the development of this capability in monkeys trained to look away from a lone, bright stimulus (antisaccade task). We evaluated behavioral performance and recorded neural activity in the prefrontal cortex both before and after the transition from puberty to adulthood. Compared to when young, adult monkeys processed the stimulus more rapidly, resisted more effectively the involuntary urge to look at it, and adhered to the task rule more consistently. The spatially selective visuomotor neurons in the prefrontal cortex provided neural correlates of these behavioral changes indicative of a faster transition from stimulus-driven (exogenous) to goal-driven (endogenous) control within the time course of each trial. The results reveal parallel signatures of cognitive maturation in behavior and prefrontal activity that are consistent with improvements in attentional allocation after adolescence.