Heavy-atom-free triplet benzothiophene-fused BODIPY derivatives for lipid droplet-specific biomaging and photodynamic therapy.

Bu, Weibin; Yu, Changjiang; Man, Yingxiu; Li, Jiazhu; Wu, Qinghua; Gui, Shuangying; Wei, Yaxiong; Jiao, Lijuan; Hao, Erhong

Bu, Weibin; Yu, Changjiang; Man, Yingxiu; Li, Jiazhu; Wu, Qinghua; Gui, Shuangying; Wei, Yaxiong; Jiao, Lijuan; Hao, Erhong.

Afiliação

Bu W; The Key Laboratory of Functional Molecular Solids, Ministry of Education, School of Chemistry and Materials Science, School of Physics and Electronic Information, Anhui Normal University, Wuhu 241002, China. yuchj@ahnu.edu.cn.
Yu C; The Key Laboratory of Functional Molecular Solids, Ministry of Education, School of Chemistry and Materials Science, School of Physics and Electronic Information, Anhui Normal University, Wuhu 241002, China. yuchj@ahnu.edu.cn.
Man Y; College of Chemistry and Chemical Engineering, Yantai University, Yantai, Shandong 264005, China. jiazhu82@ytu.edu.cn.
Li J; College of Chemistry and Chemical Engineering, Yantai University, Yantai, Shandong 264005, China. jiazhu82@ytu.edu.cn.
Wu Q; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. guishy0520@126.com.
Gui S; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. guishy0520@126.com.
Wei Y; The Key Laboratory of Functional Molecular Solids, Ministry of Education, School of Chemistry and Materials Science, School of Physics and Electronic Information, Anhui Normal University, Wuhu 241002, China. yuchj@ahnu.edu.cn.
Jiao L; The Key Laboratory of Functional Molecular Solids, Ministry of Education, School of Chemistry and Materials Science, School of Physics and Electronic Information, Anhui Normal University, Wuhu 241002, China. yuchj@ahnu.edu.cn.
Hao E; The Key Laboratory of Functional Molecular Solids, Ministry of Education, School of Chemistry and Materials Science, School of Physics and Electronic Information, Anhui Normal University, Wuhu 241002, China. yuchj@ahnu.edu.cn.

Chem Commun (Camb) ; 60(72): 9809-9812, 2024 Sep 05.

Article em En | MEDLINE | ID: mdl-39163003

ABSTRACT

ABSTRACT

The twist fusion of a benzothiophene group and the introduction of a 4-methyloxystyryl donor group to the BODIPY core resulted in large spin-orbit coupling values and smaller singlet-triplet energy gaps for the novel infrared absorbed photosensitizers named BSBDP. They show a high reactive oxygen species efficiency exceeding 69% and a fluorescence quantum yield of 23% and are successfully applied in imaging-guided photodynamic therapy in vitro and in vivo.

Assuntos

Compostos de Boro; Fotoquimioterapia; Fármacos Fotossensibilizantes; Tiofenos; Compostos de Boro/química; Compostos de Boro/farmacologia; Fármacos Fotossensibilizantes/química; Fármacos Fotossensibilizantes/farmacologia; Fármacos Fotossensibilizantes/síntese química; Tiofenos/química; Tiofenos/farmacologia; Humanos; Gotículas Lipídicas/química; Gotículas Lipídicas/metabolismo; Animais; Espécies Reativas de Oxigênio/metabolismo; Camundongos; Estrutura Molecular

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Tiofenos / Compostos de Boro / Fármacos Fotossensibilizantes Limite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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