Acetate to the rescue: Acetyl-CoA facilitates placental development.

Festa, Joseph; Trefely, Sophie

Festa, Joseph; Trefely, Sophie.

Afiliação

Festa J; Epigenetics and Signalling Programmes, Babraham Institute, Cambridge CB22 3AT, UK.
Trefely S; Epigenetics and Signalling Programmes, Babraham Institute, Cambridge CB22 3AT, UK. Electronic address: sophie.trefely@babraham.ac.uk.

Cell Stem Cell ; 31(9): 1241-1243, 2024 Sep 05.

Article em En | MEDLINE | ID: mdl-39241753

ABSTRACT

ABSTRACT

While the placenta regulates nutritional exchange between mother and fetus, Yu et al. reveal that human placental development is itself nutrient-sensitive. They elucidate entwined metabolic and epigenetic transitions driving syncytialization and pinpoint a requirement for the metabolite acetyl-CoA, which is sensitive to glucose metabolism.

Assuntos

Acetilcoenzima A; Placenta; Placentação; Humanos; Gravidez; Feminino; Acetilcoenzima A/metabolismo; Placenta/metabolismo; Acetatos/metabolismo; Acetatos/farmacologia; Animais; Glucose/metabolismo; Epigênese Genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcoenzima A / Placenta / Placentação Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Cell Stem Cell Ano de publicação: 2024 Tipo de documento: Article

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