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Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study.
Thomson, Lindsay M; Niemiec, Sierra; Mancuso, Christopher A; Khailova, Ludmila; Ali, Eiman; Syed, Aneesa; Wolfe, Kelly R; Zakrzewski, Jack; Stone, Matthew; Hyslop, Robert; Frank, Benjamin S; Davidson, Jesse A.
Afiliação
  • Thomson LM; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Niemiec S; Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Mancuso CA; Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Khailova L; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Ali E; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Syed A; Department of Pathology & Laboratory Medicine, Children's Hospital Colorado, Aurora, CO.
  • Wolfe KR; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Zakrzewski J; Deparment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Stone M; Deparment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Hyslop R; Heart Institute, Children's Hospital Colorado, Aurora, CO.
  • Frank BS; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Davidson JA; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address: jesse.davidson@childrenscolorado.org.
J Pediatr ; 276: 114322, 2024 Sep 19.
Article em En | MEDLINE | ID: mdl-39306320
ABSTRACT
This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving postoperative extracorporeal membrane oxygenation support after congenital heart disease surgery, including differential responses in those not surviving to hospital discharge. Tissue hypoxia and mitochondrial-associated proteins may represent novel candidate biomarkers for poor extracorporeal membrane oxygenation outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Pediatr Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Pediatr Ano de publicação: 2024 Tipo de documento: Article