Involvement of chromosomes 12 and 14 in the cutaneous stage of mycosis fungoides: cytogenetic evidence for a multistep pathogenesis of the disease.
Cancer Genet Cytogenet
; 20(3-4): 287-92, 1986 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-3943067
ABSTRACT
Cytogenetic studies were performed on the cells of bone marrow, peripheral blood, and skin tumor biopsies from a patient with mycosis fungoides at an early stage. Chromosome abnormalities were detected in 100% of the cells harvested from the cutaneous specimen, whereas the cells of the bone marrow and blood were karyotypically normal. Three related clones, showing increasing cytogenetic complexity, were found. Chromosome #12 was abnormal in all metaphases, and an abnormal 14q chromosome was present in a minority of cells belonging to the most complex emerging subclone. These data, along with the findings of important signs of chromosome imbalance, suggest a polyphasic evolution of this chronic T lymphoproliferative disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Cromossomos Humanos 13-15
/
Cromossomos Humanos 6-12 e X
/
Micose Fungoide
Tipo de estudo:
Etiology_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
1986
Tipo de documento:
Article