Genotoxicity of formaldehyde in cultured human bronchial fibroblasts.
Science
; 228(4695): 89-91, 1985 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-3975633
ABSTRACT
Formaldehyde, a common environmental pollutant, inhibits repair of O6-methylguanine and potentiates the mutagenicity of an alkylating agent, N-methyl-N-nitrosourea, in normal human fibroblasts. Because formaldehyde alone also causes mutations in human cells, the compound may cause genotoxicity by a dual mechanism of directly damaging DNA and inhibiting repair of mutagenic and carcinogenic DNA lesions caused by other chemical and physical carcinogens.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reparo do DNA
/
Formaldeído
/
Mutagênicos
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1985
Tipo de documento:
Article