Cyclazocine and norepinephrine uptake, metabolism, and turnover in the rat brain.
J Pharm Sci
; 74(1): 97-9, 1985 Jan.
Article
em En
| MEDLINE
| ID: mdl-3981430
ABSTRACT
The effects of cyclazocine, a narcotic agonist/antagonist, on the uptake, metabolism, and turnover of norepinephrine in rat brains were studied. Cyclazocine significantly depressed the accumulation of intracisternally administered [3H]norepinephrine and the formation of 3,4-[3H]dihydroxymandelic acid but did not alter the formation of [3H]-normetanephrine. Comparatively, imipramine reduced the uptake of [3H]norepinephrine, decreased the formation of 3,4-[3H]dihydroxymandelic acid, and increased the formation of [3H]normetanephrine. Moreover, cyclazocine increased the formation of endogenous 3-methoxy-4-hydroxyphenylethylene glycol and produced a fall in endogenous norepinephrine. It is suggested that cyclazocine reduces the accumulation of [3H]norepinephrine, decreases endogenous norepinephrine levels, and increases the formation of 3-methoxy-4-hydroxyphenylethylene glycol by interacting with brain adrenergic nerves, presumably by inhibiting neuronal uptake and facilitating norepinephrine turnover.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Norepinefrina
/
Ciclazocina
Limite:
Animals
Idioma:
En
Revista:
J Pharm Sci
Ano de publicação:
1985
Tipo de documento:
Article