Senescence and the retinal pigment epithelium: alterations in basal plasma membrane morphology.
Mech Ageing Dev
; 30(1): 99-105, 1985 Apr.
Article
em En
| MEDLINE
| ID: mdl-3999816
ABSTRACT
Marked age-related changes in the morphology of retinal pigment epithelial (RPE) cell basal infoldings were found in pigmented rats. Quantitative morphometric analysis revealed that during senescence the amount of basal plasma membrane per unit RPE length increased substantially, the regional distribution of the basal infoldings along the RPE became more irregular, and the average depth of penetration of the basal infoldings into the RPE increased dramatically. The crucial role of the RPE in maintaining retinal integrity suggests that the observed changes in RPE morphology may be involved in the development of senile retinopathies which occur in a variety of species, including man.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Epitélio Pigmentado Ocular
/
Envelhecimento
/
Membrana Celular
Limite:
Animals
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
1985
Tipo de documento:
Article