Facile preparation of 6-chloro-9-amino-2-hydroxyacridine, a urinary metabolite of quinacrine and quinacrine mustard.
J Pharm Sci
; 64(8): 1418-9, 1975 Aug.
Article
em En
| MEDLINE
| ID: mdl-50435
ABSTRACT
6-Chloro-9-amino-2-hydroxyacridine was found to be a metabolite of both quinacrine and the antimalarial alkylating agent quinacrine mustard. Its structure was confirmed by a one-step reaction of quinacrine with 48 percent hydrobromic acid. The presence of this compound as a metabolite of quinacrine mustard suggests a possible in vivo activation mechanism for its antitumor activity and a pharmacological basis for its toxicity to the liver. In vitro experiments showed that this new compound does react with chromosomes and, therefore, can be both a useful chromosome stain and an intercalating agent.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinacrina
/
Mostarda de Quinacrina
/
Acridinas
Limite:
Animals
Idioma:
En
Revista:
J Pharm Sci
Ano de publicação:
1975
Tipo de documento:
Article