Mammary tumour inhibition and subacute toxicity in rats of prednimustine and of its molecular components chlorambucil and prednisolone.
Acta Pharmacol Toxicol (Copenh)
; 42(3): 159-63, 1978 Mar.
Article
em En
| MEDLINE
| ID: mdl-580343
ABSTRACT
Prednimustine, a chlorambucil ester of pregnisolone, retarded growth of DMBA-induced mammary tumours in rats and reduced the number of tumours. A combination of chlorambucil and prednisolone (C + P) in the same proportion as in prednimustine, had similar effects, 8 and 26 mg per kg of the C + P combination being equipotnet to 16 and 64 mg per kg of prednimustine, respectively. The mortality figures suggested that prednimustine was considerably less toxic than equipotent doses of C + P. This toxicity difference was confirmed in a parallel investigation of the subacute toxicity in rats of prednimustine and C + P. This study showed that the mortality, reduction of lymphocytes and platelets, and bone marrow depression was much lower after pregnimustine than after equimolar amounts of the C + P combination. The results suggest that the low toxicity of prednimustine makes this drug a better cytostatic agent than the C + P combination treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prednisolona
/
Clorambucila
/
Neoplasias Mamárias Experimentais
Limite:
Animals
Idioma:
En
Revista:
Acta Pharmacol Toxicol (Copenh)
Ano de publicação:
1978
Tipo de documento:
Article