Isolation and properties of the leukocytosis- and lymphocytosis-promoting factor of Bordetella pertussis.
J Exp Med
; 143(6): 1483-502, 1976 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-58054
ABSTRACT
The leukocytosis- and lymphocytosis-promoting factor (LPF) of Bordetella pertussis has been isolated to near homogeneity by physical, chemical, and electron microscopical criteria. LPF contains 14.5% nitrogen and is lipid and carbohydrate free. It is apparently composed of four polypeptide subunits. LPF caused leukocytosis and lymphocytosis in "nude" as well as in normal mice. In addition, purified LPF also induced histamine sensitization and hypoglycemia and refractoriness to the hyperglycemic effect of epinephrine. A monospecific LPF antiserum blocked these reactions as well as leukocytosis and lymphocytosis. LPF is clearly distinct from the hemagglutinating pili of B. pertussis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Bordetella pertussis
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Leucocitose
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Linfocitose
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Antígenos de Bactérias
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1976
Tipo de documento:
Article