IgA-dependent, monocyte-mediated, antibacterial activity.
J Exp Med
; 152(2): 452-7, 1980 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-6156988
ABSTRACT
IgA purified from the sera of patients convalescing from disseminated group C meningococcal disease induced human monocyte-mediated anti-meningococcal activity in vitro in the absence of complement. Both IgA- and IgG-dependent activity were directed against the group C meningococcal polysaccharide (Csss) capsule. The amount of IgA that was effective bound less than 1 ng of Csss. Antibacterial activity was dependent upon the length and the temperature of the test incubation and on the concentration of monocytes. The implications of this mechanism for local cell-mediated antibacterial immunity are discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina A
/
Monócitos
/
Neisseria meningitidis
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1980
Tipo de documento:
Article