Effect of interferon on pluripotent hemopoietic progenitors (CFU-GEMM) derived from human bone marrow.
Exp Hematol
; 10(7): 587-90, 1982 Aug.
Article
em En
| MEDLINE
| ID: mdl-6182013
ABSTRACT
A culture assay for multilineage hemopoietic progenitors (CFU-GEMM) that form mixed hematopoietic colonies containing granulocytes, erythroblasts, megakaryocytes and macrophages was described. The effect of human leukocyte interferon on multilineage hemopoietic progenitors was examined. Leukocyte interferon does reduce the plating efficiency of noncommitted precursors (CFU-GEMM) in a dose related fashion. A reduction of the plating efficiency of mixed hemopoietic colonies was observed even when interferon was added 72 hours after initiation of the cultures.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células da Medula Óssea
/
Células-Tronco Hematopoéticas
/
Interferons
/
Hematopoese
Limite:
Humans
Idioma:
En
Revista:
Exp Hematol
Ano de publicação:
1982
Tipo de documento:
Article