Remission of pituitary-dependent Cushing's disease after removal of nonneoplastyic pituitary gland.
Arch Intern Med
; 140(10): 1366-8, 1980 Oct.
Article
em En
| MEDLINE
| ID: mdl-6252859
ABSTRACT
Transsphenoidal hypophysectomy was performed on a 28-year-old woman with pituitary-dependent Cushing's disease. Both clinical and chemical resolution of the hypercortisolism was achieved in spite of no evident pituitary microadenoma or cell hyperplasia. Histologic examination revealed widespread Crooke's changes and normal relative numbers, size, and distribution of corticotrophs. We propose that rare patients with pituitary-dependent Cushing's disease may have excessive pituitary production of adrenocorticotropic hormone in the absence of an adenoma or corticotroph cell hyperplasia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Cushing
/
Hipofisectomia
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Arch Intern Med
Ano de publicação:
1980
Tipo de documento:
Article