[Clinical value of N-acetyl-beta-D-glucosaminidase and alpha-galactosidase in liver diseases]. / Zur klinischen Wertigkeit der N-Azetyl-beta-D-Glukosamminidase and alpha-Galaktosidase bei Lebererkrankungen.

ABSTRACT

N-acetyl-beta-D-glucosaminidase is a lysosomal glycosidase, which participates in the catabolism of the mucopolysaccharides and of the glycoproteins. For the determination of this enzyme the production of the substrate and a modified methodology are described. Measurements of the activity were performed by 4-nitrophenyl-alpha-D-galactopyranoside and 4-nitrophenyl-N-acetyl-beta-D-glucosaminide as substrates. Examinations of this enzyme were performed in patients with acute virus hepatitis, chronic hepatitis, liver cirrhosis and healthy test persons. In acute hepatitis and liver cirrhosis and significant increase of enzyme is provable, but not in protracted hepatitis.