Acyclovir chemistry and spectrum of activity.

ABSTRACT

Most antiviral agents with activity against the herpes group of viruses belong to a class of compounds known as nucleosides. Recently, an acyclic analog of a natural nucleoside has been found to have high activity against the herpes virus. This compound, called generically acyclovir, is 9-(hydroxymethyl)guanine. Its spectrum of antiviral activity is described.