Forskolin stimulates the conversion of tyrosine to dopamine in catecholaminergic neural tissue.
Brain Res
; 264(1): 173-7, 1983 Mar 28.
Article
em En
| MEDLINE
| ID: mdl-6303497
ABSTRACT
Forskolin stimulates the conversion of tyrosine to dopamine in slices and synaptosomes from rat striatum, in synaptosomes from rat hypothalamus, and in slices from bovine retina. In striatal synaptosomes, there is an approximately 80% stimulation of dopamine formation from tyrosine, but no effect with DOPA as substrate, suggesting that the effect is on tyrosine hydroxylase. Stimulation is saturable with a half-maximal effect at under 1 microM forskolin. Forskolin stimulation is additive with, and hence independent of , activation due to KCl, but not that due to dibutyryl-cyclic AMP. Stimulation of dopamine synthesis by forskolin may provide an approach for elucidating the regulation of the adenylate cyclase system associated with catecholaminergic nerve endings.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Sinaptossomos
/
Tirosina
/
Catecolaminas
/
Dopamina
/
Corpo Estriado
/
Diterpenos
/
Hipotálamo
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1983
Tipo de documento:
Article