The subcellular distribution of renin in hog anterior pituitary.

ABSTRACT

Renin in hog anterior pituitary was found to be located principally in the particulate fractions. Density gradient centrifugation of the granular fraction revealed a discrete band of renin activity distinct from lysosomal and mitochondrial markers. This band has a density similar to that of known kidney renin secretory granules and may be due to renin secretory or storage granules in the anterior pituitary.