Soluble HLA antigens not detected in human immunoglobulin preparations.
Tissue Antigens
; 22(1): 59-61, 1983 Jul.
Article
em En
| MEDLINE
| ID: mdl-6612705
ABSTRACT
Immunoglobulin concentrates prepared from subjects of known HLA specificity were assayed for the presence of soluble HLA antigens by the inhibition of cytotoxic HLA alloantisera using a microabsorption procedure. The immunoglobulin preparations inhibited alloantisera of all specificities tested, regardless of the HLA type of the immunoglobulin donor, indicating that the observed inhibition was non-specific. Addition of extra complement reduced the inhibitory effects of the immunoglobulin concentrates. It is concluded that the inhibition of HLA alloantisera demonstrated by this technique is due to the anticomplementary activity of the immunoglobulin preparations, rather than their content of specific soluble HLA antigens.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulinas
/
Antígenos HLA
Limite:
Humans
Idioma:
En
Revista:
Tissue Antigens
Ano de publicação:
1983
Tipo de documento:
Article