Quantitative determination of haloperidol in human plasma by high-performance liquid chromatography.
Ther Drug Monit
; 5(4): 485-9, 1983.
Article
em En
| MEDLINE
| ID: mdl-6659018
ABSTRACT
We present a method for the quantitative determination of haloperidol in human plasma. The high-performance liquid chromatographic method of analysis is a significant advancement in terms of ease and speed of haloperidol determination. The drug and the internal standard, chlorohaloperidol, are extracted from 2.0 ml of serum or plasma, back-extracted into the aqueous mobile phase, separated on a C-18 reversed-phase column, and monitored at 254 nm. The potential interference by other drugs was evaluated and was found to be negative. The method is sensitive to at least 5 ng/ml of extracted material and is suitable for drug measurement in the therapeutic range (5-20 ng/ml) and in the toxic range (greater than 50 ng/ml).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Haloperidol
Limite:
Humans
Idioma:
En
Revista:
Ther Drug Monit
Ano de publicação:
1983
Tipo de documento:
Article