Improved radioimmunodetection of tumours using liposome-entrapped antibody.
Biochim Biophys Acta
; 762(2): 154-64, 1983 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-6830870
ABSTRACT
The discrimination of radioimmunodetection of tumours is reduced by the presence of circulating radiolabelled antibody (primary antibody). We have prepared liposomes containing an antibody to the primary antibody (secondary antibody), with the intention of complexing and delivering to the liver primary antibody which is not associated with the tumour. In mice bearing xenografts of human tumours which secrete the marker carcinoembryonic antigen (CEA), liposomally entrapped secondary antibody was able to reduce the blood levels of 125I-labelled anti-CEA within 2 h, without reducing the amount of anti-CEA bound to the tumour. We therefore suggest that the use of liposomally entrapped secondary antibody would improve the diagnostic potential of radioimmunodetection of tumours and their metastases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Retais
/
Antígeno Carcinoembrionário
/
Neoplasias do Colo
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Lipossomos
/
Anticorpos Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1983
Tipo de documento:
Article