Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen.
J Exp Med
; 154(2): 535-40, 1981 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-7021752
ABSTRACT
Outbred Wistar rats immunized with native type II collagen developed ear lesions resembling those of human relapsing chondritis. As in human disease, these lesions were characterized by intense chondritis, positive immunofluorescence reactions to IgG and C3, and circulating IgG reactive with native type II collagen. Furthermore, electron-dense deposits were seen near the surface of chondrocytes and corresponded with deposits of IgG and C3. These observations suggest a causal relation between humoral immunity to type II collagen and auricular chondritis in the rat and support the hypothesis than human relapsing polychondritis is an autoimmune disease mediated by immunity to type II collagen.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Policondrite Recidivante
/
Modelos Animais de Doenças
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1981
Tipo de documento:
Article