Enzyme induction following a single dose of amobarbital in dogs.
J Pharmacokinet Biopharm
; 6(4): 305-13, 1978 Aug.
Article
em En
| MEDLINE
| ID: mdl-702272
ABSTRACT
The elimination of amobarbital in dogs was investigated by injecting various doses of amobarbital into a given animal. At low doses (3 mg/kg) serum levels declined in a first-order fashion. Superficially, at high doses (20 mg/kg) the relationship between serum concentration and time could be quantitatively characterized by simple one-compartment saturable kinetics. Indeed, qualitatively, saturation of the amobarbital-metabolizing enzymes was indicated by a shallower initial slope of the semilogarithmic concentration--time profile at the high than at the low dose. However, in addition, an acute enzyme induction phenomenon was observed which was indicated by a shorter terminal half-life of amobarbital at the high dose than after the low dose and also by a shortening in antipyrine half-life.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amobarbital
Limite:
Animals
Idioma:
En
Revista:
J Pharmacokinet Biopharm
Ano de publicação:
1978
Tipo de documento:
Article