Lymphocytes bearing single or double surface immunoglobulins in umbilical cord blood.
Allergol Immunopathol (Madr)
; 9(2): 113-8, 1981.
Article
em En
| MEDLINE
| ID: mdl-7027776
ABSTRACT
Lymphocytes from the umbilical cord blood of 20 newborn infants and the peripheral blood of 18 adult volunteers, were studied for surface-stable immunoglobulins by the direct immunofluorescence technique. Goat antiserums to human light and heavy chains were used. Cord blood yielded a significantly higher percentage of lymphocyte bearing mu + delta chains, and a lower percentage bearing only delta chains. The number of B cells bearing light chains (K + lambda) or heavy chains (mu + delta +(mu + delta) was higher in cord blood than in the adult peripheral blood. The high percentage of cells bearing double markers (probably virgin B-cells) and the low number of cells bearing only IgD, (probably the cells responsible for secondary antibody responses) could be explained by the inhibition of the IgM-to-IgG switch in the antibody production of newborns.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina M
/
Linfócitos B
/
Sangue Fetal
Limite:
Adult
/
Humans
/
Newborn
Idioma:
En
Revista:
Allergol Immunopathol (Madr)
Ano de publicação:
1981
Tipo de documento:
Article