Cefamandole bone diffusion in patients undergoing total hip replacement.
Chemotherapy
; 27(3): 166-72, 1981.
Article
em En
| MEDLINE
| ID: mdl-7226972
ABSTRACT
Cefamandole penetration was studied in 32 normal bone specimens. No antibiotic bone binding was found. Blood contamination of bone samples was measured by the haemoglobin method. Mean corrected levels attained (5.8 micrograms/g) exceed MIC values of sensitive Staphylococcus aureus, Haemophilus influenzae and Enterobacteriaceae. Similar diffusion was observed in cortical and trabecular bone. The results obtained invite further studies on preoperative prophylaxis and treatment of osteomyelitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osso e Ossos
/
Cefamandol
/
Cefalosporinas
/
Prótese de Quadril
Limite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Chemotherapy
Ano de publicação:
1981
Tipo de documento:
Article