Simulation of massive periretinal proliferation by autotransplantation of retinal pigment epithelial cells in rabbits.
Am J Ophthalmol
; 91(1): 76-87, 1981 Jan.
Article
em En
| MEDLINE
| ID: mdl-7234933
ABSTRACT
We compared the clinical pattern, the histologic findings, and the electron microscopic appearance of lesions produced by the autotransplantation into rabbit vitreous of freshly harvested and tissue-cultured (250,000) retinal pigment epithelial cells. Both harvested and cultured cells formed intravitreal strands, traction detachments, and retinal puckers, resembling the most prominent features of massive periretinal proliferation in humans. Strands produced by both types of retinal pigment epithelial cells contained cells resembling myofibroblasts which may explain the contractability of the strand. The clinical, histologic, and electron microscopic observations were similar to those found in eyes injected with tissue-cultured skin fibroblasts.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Epitélio Pigmentado Ocular
Limite:
Animals
Idioma:
En
Revista:
Am J Ophthalmol
Ano de publicação:
1981
Tipo de documento:
Article