Induction by phenobarbital of ornithine decarboxylase activity in rat liver after initiation with diethylnitrosamine.

ABSTRACT

Dietary administration of 0.1% phenobarbital (PB) for 1-2 weeks increased ornithine decarboxylase (ODC) activity slightly but to a significant extent (P less than 0.05) in livers of rats into which diethylnitrosamine (DEN) (200 mg/kg body wt) had been injected intraperitoneally 2 weeks before phenobarbital feeding. The increase was observed only under the controlled feeding schedule which avoided the effect of food intake.