Expression of TEM-induced damage to postmeiotic stages of spermatogenesis of the mouse during early embryogenesis. II. Cytological investigations.
Mutat Res
; 52(1): 107-15, 1978 Oct.
Article
em En
| MEDLINE
| ID: mdl-732859
ABSTRACT
After treatment of postmeiotic stages of spermatogenesis of the mouse with TEM (0.2 or 0.4 mg/kg), dose- and stage-of-spermatogenesis-dependent frequencies of cytogenetic aberrations can be observed in early embryos. The frequencies of first-cleavage metaphases exhibiting structural aberrations (all of the chromosome type), the frequencies of 2 cell embryos and of 4--8 cell embryos containing nuclei accompanied by micronuclei or nuclei connected by bridges show a close correlation to frequencies of preimplantation loss of embryos recorded in a dominant lethal test. The frequencies of morulae/blastulae exhibiting blastomeres with micronuclei show a close correlation to the frequencies of total (pre- and post-implantation) loss of embryos. This indicates delayed expression of TEM-induced chromosomal damage which could persist undetected in very early stages of embryogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espermatócitos
/
Espermatogênese
/
Espermatozoides
/
Trietilenomelamina
/
Aberrações Cromossômicas
/
Cromossomos
Limite:
Animals
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
1978
Tipo de documento:
Article