The Icr:Ha(ICR) mouse: a current account of breeding, mutations, diseases and mortality.

ABSTRACT

This stock of albino mice is minimally inbred (0.5% per generation), and has been rigidly selected for fecundity. It is widely employed in oncological and pharmaceutical research. Spontaneous tumours arose in 55% of animals, multiple in 28%, averaging 1.66 per mouse. Females developed tumours at an earlier age than males. Predominant tumour types were pulmonary (23.1%), lymphoreticular (20%), and mammary (14%--23% of females). Miscellaneous tumour types (42.9%) ranged in frequency from 0.2 to 2.0%, the latter being hepatomas. Distribution of mammary tumours indicated that milk-borne mammary tumour virus was absent. Non-neoplastic disease was present in 58.6%, 24.1% being pulmonary and predominant in the young, while renal (31.2%) and cardiovascular (10.2%) disease was common in the elderly. Males outlived females.