New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide.
J Med Chem
; 23(6): 702-4, 1980 Jun.
Article
em En
| MEDLINE
| ID: mdl-7392039
Schiff bases of gamma-aminobutyric acid (gammaAbu) and gamma-aminobutyramide (gammaAbuNH2) were prepared and tested for anticonvulsant and gammaAbu mimetic activity. 4-[[(4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]butanoic acid monosodium salt (4) and 4-[[(4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]butanamide (5) blocked bicuculline-induced lethality and convulsions and displaced [3H]gammaAbu from its membrane binding sites. In the rat dorsal root sensory ganglion, compound 4 exhibited gammaAbu agonist properties. Compounds 4 and 5 are thus anticonvulsants and directly acting gammaAbu mimetics.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido gama-Aminobutírico
/
Anticonvulsivantes
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1980
Tipo de documento:
Article