Stereochemical requirements for cannabinoid activity.
J Med Chem
; 23(10): 1068-72, 1980 Oct.
Article
em En
| MEDLINE
| ID: mdl-7420350
ABSTRACT
Several pairs of cannabinoid isomers were synthesized and tested for psychotropic activity in rhesus monkeys. Two regularities were observed (a) In the absence of the other substituents, the equatorial stereochemistry of the substituent at C-1 determines activity. (b) Two groups of THC-type cannabinoids which differ only in that the chemical groupings in one of them at C-1, C-2 are situated at C-1, C-6 in the other (but retain their stereochemistry) have almost equivalent psychotropic activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canabinoides
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1980
Tipo de documento:
Article