A mouse model of spontaneous renal hypertension. blood pressure, heart weight, kidney weight and proteinuria relationships in NZB x OUW F1 hybrid female mice.

ABSTRACT

Data concerning blood pressure, kidney weight, heart weight and proteinuria were obtained from different groups of BW mice. Relatively early in life, systolic blood pressures as measured by a tail-cuff method, were above the upper limits of normal, continued to rise with increasing age and had peak average values coinciding with the peak death period and increased proteinuria. Any relationships which might exist among age, body weight and heart weight or kidney weight were sought by computerized polynomial multivariate analysis. It was found that, although there was only a slight effect with increasing body weight, both heart weight and kidney weight showed a steady increase with increasing age. These data support the proposal that the BW female mouse is a good model of spontaneous renal hypertension.