Binding of human beta 2-microglobulin to murine EL4 thymoma cells upregulates MHC class I heavy-chain epitopes, inhibits IL-2 secretion and induces resistance to killing by natural killer cells.
Immunol Lett
; 39(2): 195-202, 1994 Feb.
Article
em En
| MEDLINE
| ID: mdl-7516913
ABSTRACT
A variety of murine tumor cell lines was studied for its binding of exogeneously added human beta 2-microglobulin (h beta 2m). Three T lymphomas and one IL-2-dependent T-cell line (HT-1) bound substantial amounts of h beta 2m, whereas P815 mastocytoma cells, an Abelson virus-infected pre-B cell line (ABLS-8), X63 B-lymphoma cells and YAC cells did not bind h beta 2m. In two of the T lymphomas, EL4 and BW5147, binding of h beta 2m led to an increase in major histocompatibility complex class I (MHC-I) heavy-chain epitope expression as measured by anti-H-2K/D antibody binding and FACS analysis. EL4 cells which had bound h beta 2m decreased their rate of constitutive IL-2 secretion and became resistant to activated natural killer (NK) cell killing. The present data suggest the binding of h beta 2m to mouse T cells leads to conformational changes of MHC-I heavy chains which influence both effector and target functions of the cell.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Antígenos de Histocompatibilidade Classe I
/
Linfoma de Células T
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Microglobulina beta-2
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Interleucina-2
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Citotoxicidade Imunológica
/
Epitopos
Limite:
Animals
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Dinamarca