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Binding of human beta 2-microglobulin to murine EL4 thymoma cells upregulates MHC class I heavy-chain epitopes, inhibits IL-2 secretion and induces resistance to killing by natural killer cells.
Claësson, M H; Nissen, M H.
Afiliação
  • Claësson MH; Laboratory for Cellular Immunology, Panum Institute, University of Copenhagen, Denmark.
Immunol Lett ; 39(2): 195-202, 1994 Feb.
Article em En | MEDLINE | ID: mdl-7516913
ABSTRACT
A variety of murine tumor cell lines was studied for its binding of exogeneously added human beta 2-microglobulin (h beta 2m). Three T lymphomas and one IL-2-dependent T-cell line (HT-1) bound substantial amounts of h beta 2m, whereas P815 mastocytoma cells, an Abelson virus-infected pre-B cell line (ABLS-8), X63 B-lymphoma cells and YAC cells did not bind h beta 2m. In two of the T lymphomas, EL4 and BW5147, binding of h beta 2m led to an increase in major histocompatibility complex class I (MHC-I) heavy-chain epitope expression as measured by anti-H-2K/D antibody binding and FACS analysis. EL4 cells which had bound h beta 2m decreased their rate of constitutive IL-2 secretion and became resistant to activated natural killer (NK) cell killing. The present data suggest the binding of h beta 2m to mouse T cells leads to conformational changes of MHC-I heavy chains which influence both effector and target functions of the cell.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Antígenos de Histocompatibilidade Classe I / Linfoma de Células T / Microglobulina beta-2 / Interleucina-2 / Citotoxicidade Imunológica / Epitopos Limite: Animals Idioma: En Revista: Immunol Lett Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Dinamarca
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Antígenos de Histocompatibilidade Classe I / Linfoma de Células T / Microglobulina beta-2 / Interleucina-2 / Citotoxicidade Imunológica / Epitopos Limite: Animals Idioma: En Revista: Immunol Lett Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Dinamarca