Human peripheral blood granulocytes and myeloid leukemic cell lines express both transcripts encoding for stem cell factor.
Stem Cells
; 12(5): 521-6, 1994 Sep.
Article
em En
| MEDLINE
| ID: mdl-7528592
ABSTRACT
Stem cell factor (SCF), the ligand for the c-kit proto-oncogene, has been shown to play a critical role in the migration of melanocytes and germ cells during embryogenesis as well as in the proliferative control of the hematopoietic compartment. In this study we investigated the expression of both the soluble and transmembrane SCF forms in purified peripheral blood populations and in several hematopoietic cell lines. Expression of both transcripts, though in different ratios, was identified in whole bone marrow, in bone marrow stromal cells and in human peripheral blood. In peripheral blood, SCF expression could be ascribable to polymorphonuclear leukocytes (PMN), whereas no SCF expression was detected in isolated lymphocytes, monocytes and in some T lymphoid cell lines. Conversely, some hematopoietic myeloid cell lines, such as HL-60, KG1 and K562, express SCF with similar patterns.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
/
RNA Mensageiro
/
RNA Neoplásico
/
Leucemia Mieloide
/
Regulação da Expressão Gênica
/
Fatores de Crescimento de Células Hematopoéticas
/
Proteínas de Membrana
/
Proteínas de Neoplasias
/
Neutrófilos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Stem Cells
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Itália