Origin of the glomerular vasculature in the developing kidney.
Semin Nephrol
; 15(4): 300-14, 1995 Jul.
Article
em En
| MEDLINE
| ID: mdl-7569410
ABSTRACT
Mechanisms regulating the establishment of the glomerular endothelium and mesangium during glomerulogenesis are not understood. In this article, we discuss two different blood vessel growth processes vasculogenesis and angiogenesis, with particular attention on how these processes might operate in the developing kidney. Results from metanephric organ cultures and interspecies grafts are also interpreted with an emphasis on generation of the renal microvasculature. Among the several growth factors identified in the metanephros, many (eg, fibroblast growth factor [FGF], vascular endothelial growth factor [VEGF], platelet-derived growth factor [PDGF], epidermal growth factor/transforming growth factor-alpha [EGF/TGF-alpha], hepatocyte growth factor/scatter factor [HGF/SF], and insulinlike growth factor [IGF]) have angiogenic properties, and these are discussed in relation to formation of the glomerulus. How extracellular matrices and proteases might be involved in vascularization are also considered.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endotélio Vascular
/
Glomérulos Renais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Semin Nephrol
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos