Suggestive evidence for a DA D3 receptor-mediated increase in the release of oxytocin in the male rat.
Neuroreport
; 6(9): 1338-40, 1995 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-7669999
ABSTRACT
The dopamine (DA) D2/3 receptor agonists quinpirole (0.5-8.0 mg kg-1, s.c.) and 7-OH-DPAT (0.2-3.2 mg kg-1, s.c.), but not the preferential DA D2 receptor agonist bromocriptine (2.0-32.0 mg kg-1, s.c.), produced increased plasma oxytocin levels in the rat. In keeping with their affinity for the DA D2 receptor, all three compounds produced a marked suppression of plasma prolactin levels in their respective dose range. It is suggested that DA D3 receptors are involved in mechanisms regulating oxytocin secretion in the rat.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ocitocina
/
Receptores Dopaminérgicos
/
Agonistas de Dopamina
/
Ergolinas
Limite:
Animals
Idioma:
En
Revista:
Neuroreport
Assunto da revista:
NEUROLOGIA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Suécia