Preferential migration of activated CD4+ and CD8+ T cells in response to MIP-1 alpha and MIP-1 beta.
Science
; 260(5106): 355-8, 1993 Apr 16.
Article
em En
| MEDLINE
| ID: mdl-7682337
ABSTRACT
Recombinant human macrophage inflammatory protein-1 alpha (rhMIP-1 alpha) and rhMIP-1 beta were potent chemoattractants of human T lymphocytes. These rhMIP-1 cytokines attracted only T cells activated by monoclonal antibody to CD3 and did not attract unstimulated lymphocytes. Phenotypic analysis revealed that CD4+ T cells were capable of migrating in response to rhMIP-1 beta, whereas rhMIP-1 alpha induced chemotaxis of predominantly CD8+ T lymphocytes. Activated naïve and memory T cells also migrated in response to rhMIP-1 cytokines. Furthermore, these cytokines enhanced the ability of T cells to bind to an endothelial cell monolayer. These results suggest that rhMIP-1 cytokines preferentially recruit specific T cell subsets during the evolution of the immune response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
/
Linfócitos T Citotóxicos
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Linfócitos T CD4-Positivos
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Quimiotaxia de Leucócito
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Citocinas
/
Monocinas
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Linfócitos T Reguladores
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1993
Tipo de documento:
Article