Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice.
Science
; 262(5135): 907-9, 1993 Nov 05.
Article
em En
| MEDLINE
| ID: mdl-7694362
ABSTRACT
B7 delivers a costimulatory signal through CD28, resulting in interleukin-2 secretion and T cell proliferation. Blockade of this pathway results in T cell anergy. The in vivo role of B7 was evaluated with B7-deficient mice. These mice had a 70 percent decrease in costimulation of the response to alloantigen. Despite lacking B7 expression, activated B cells from these mice bound CTLA-4 and GL1 monoclonal antibody, demonstrating that alternative CTLA-4 ligand or ligands exist. These receptors are functionally important because the residual allogenic mixed lymphocyte responses were blocked by CTLA4Ig. Characterization of these CTLA-4 ligands should lead to strategies for manipulating the immune response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Linfócitos T
/
Antígenos de Diferenciação
/
Antígeno B7-1
/
Imunoconjugados
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Marrocos