Centromere spreading and centromeric aberrations in ovarian tumors.
Cancer Genet Cytogenet
; 80(1): 63-5, 1995 Mar.
Article
em En
| MEDLINE
| ID: mdl-7697635
ABSTRACT
Centromere spreading (CS) of chromosomes and high occurrence of aberrations at centromeric region were observed in two papillary serous cystadenocarcinomas and one borderline papillary serous cystadenoma of the ovary. In the borderline tumor, CS of chromosome 12, trisomy of which had been reported as the sole abnomaly in benign ovarian tumors, was seen in three metaphases. It is suggested that CS may be an early event in the carcinogenesis of epithelial ovarian tumors. Centromeres of some chromosomes in tumor cells may be unstable and thus bring about premature centromere separations and breakages at centromeric regions, followed by some numerical and structural chromosomal aberrations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Centrômero
/
Aberrações Cromossômicas
/
Cistadenocarcinoma Papilar
Limite:
Female
/
Humans
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
1995
Tipo de documento:
Article