Stable antiviral expression (SAVE) as an approach to somatic cell gene therapy directed against HIV infection.
Hokkaido Igaku Zasshi
; 69(6): 1288-93, 1994 Nov.
Article
em En
| MEDLINE
| ID: mdl-7705744
ABSTRACT
We are developing methods for somatic cell gene therapy directed against infection with human immunodeficiency virus by enhancing the antiviral resistance of target cells through the constitutive production of interferon-beta. Cells that have been transformed by plasmids or retroviral vectors carrying the human interferon-beta gene placed under the expression control of a murine H2Kb promoter fragment become resistant to HIV infection. Part of this enhanced resistance is due to inhibition of virus entry into the transformed cells, a hitherto unreported mechanism of interferon action.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Regulação Viral da Expressão Gênica
/
Infecções por HIV
/
Interferon beta
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Hokkaido Igaku Zasshi
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
França