A deletion polymorphism in the angiotensin converting enzyme gene is not associated with coronary heart disease in an Austrian population.
Atherosclerosis
; 112(2): 137-43, 1995 Jan 20.
Article
em En
| MEDLINE
| ID: mdl-7772074
ABSTRACT
This study examined a possible relationship between genetic variation in the gene coding for the angiotensin converting enzyme (ACE) and increased risk for coronary heart disease (CHD) in an Austrian population. Polymerase chain reaction (PCR) was used to determine the genotypes for an insertion/deletion polymorphism in intron 16 of the ACE gene in 315 patients with CHD and in 149 normal controls. In the control group, the relative allele frequencies of the polymorphism were similar to those of previously published European studies. The genotype distribution among our patients was not significantly different from that among controls. We were not able to show a significant association of the DD genotype with coronary heart disease in subgroups containing patients considered at low coronary risk. There was no association of lipid parameters and ACE genotype. From these data we conclude that, in the Austrian population, the insertion/deletion polymorphism in the ACE gene cannot be used as a marker for coronary risk assessment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptidil Dipeptidase A
/
Doença das Coronárias
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Atherosclerosis
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Áustria